TNF and Cognitive impairment: At the same time, cognitive deficits in SIRT1 knock‐out (KO) mice have been associated with defects in synaptic plasticity (Michán et al., 2010), and DHA‐PL and EPA‐PL have been shown to inhibit TNF‐α‐induced lipolysis in 3T3‐L1 adipocytes by activating the SIRT1 pathways (Yang et al., 2021).