However, it is important to note that the TWEAK/Fn14 pathway is involved in many other tissues and pathologies such as tumor development and metastasis, heart-related diseases [80], kidney injury, cerebral ischemia [81, 82] and autoimmune diseases [83, 84], which could have influenced the overall impact of systemically administered Fc-TWEAK on muscle health and disease progression in SMA mice. This evidence concerns the gene TNFSF12 and brain ischemia.