We thus show a shared pattern of aberrantly expressed genes that modulate myogenesis, myopathy and glucose metabolism in SMA, Tweak-depleted, and Fn14-depleted skeletal muscle, suggesting that Smn, Tweak, and Fn14 may act synergistically on muscle pathology and metabolism defects in SMA muscle. Here, TNFSF12 is linked to proximal spinal muscular atrophy.