SPRY4 and asthma: The Group 2 (TNFα exposure-associated) JAK-STAT signaling pathway genes that were overrepresented included IL10RB, IL13RA2, IL15RA, IL7R, LEP, STAT1, STAT4, while the Group 3 (CEBPD knockdown- and TNFα exposure-associated) JAK-STAT signaling pathway genes included CCND3, IL24, IL6R, LIF, PIM1, SOCS1, SOCS2, SOCS3, SPRY4. We focused further on the JAK-STAT signaling pathway genes in Group 3 because its co-expression patterns were associated with a combined phenotype that most relates to the influence of CEBPD on asthma glucocorticoid responses.