The large number of differentially expressed genes observed in CEBPD siRNA versus NT siRNA transfected samples under glucocorticoid and/or TNFα exposures included expected findings, such as changes in genes related to the ontological categories interferon signaling and downstream signaling events of B cell receptor, as well as novel findings of relevance to asthma, such as the alteration of genes involved in smooth muscle contraction and nitric oxide stimulates guanylate cyclase. Here, CEBPD is linked to asthma.