Tumours with homologous recombination deficiency (HRD) including BReast CAncer gene (BRCA) mutations are found to be sensitive to polyadenosine diphosphate-ribose polymerase (PARP) inhibitors and understanding of HRD status has become important in the frontline setting. The gene discussed is PARP1; the disease is hypoparathyroidism-retardation-dysmorphism syndrome.