In unpaired analysis, we found that genes expression significantly lower in the tumor group were IL26, IL17F, KLRB1, CD40LG, genes expression significantly higher in the tumor group were IGHG2, IRF4, IGHGP, FUT7, LAX1 FCRL5, FAM30A, FPR25, NFKBIZ, IGKV3-20, ZC3H12D, and SLAMF1, compared with the normal group (Fig. 5B, and Supplementary Table 6). This evidence concerns the gene IRF4 and neoplasm.