ERBB2 and breast cancer: In a study from pivot et al. ERBB2-positive early breast cancer patients received HD201 (Trastuzumab biosimilar) and Referent Trastuzumab in a neoadjuvant setting for 8 cycles concurrently with chemotherapy, and tpCR rates were 45% for HD201 and 48.7% for referent trastuzumab [31].