RUNX1T1 and obesity due to melanocortin 4 receptor deficiency: As a mediator of adipogenesis, RUNX1T1 modulates adipocyte differentiation through its alternative isoforms, with mutual feedback between fat mass and obesity-associated (FTO) genes, which encode nucleic acid demethylase and are capable of mediating RUNX1T1 mRNA splicing by demethylating N6-methyladenosine [46].