Taking up 12% of all cases, the translocation t (8; 21)(q22; q22) is a commonly existing chromosomal abnormality found in the fusion oncogene of RUNX1-RUNX1T1, intimately relating to the AML M2 subtype in the FAB classification, which is feathered by granulocytic maturation (Gr-1 ≥ 30%) in differentiation property and morphology [19]. Here, RUNX1T1 is linked to acute myeloid leukemia.