The genetics of cohesinopathy provide evidence for RAD21, STAG2, SMC1A, and SMC3 as driver mutations in acute myeloid leukemia (AML), chronic myeloid leukemia (CML), and pre-leukemic states (myelodysplastic syndrome; MDS) [74]. Here, SMC3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.