The genetics of cohesinopathy provide evidence for RAD21, STAG2, SMC1A, and SMC3 as driver mutations in acute myeloid leukemia (AML), chronic myeloid leukemia (CML), and pre-leukemic states (myelodysplastic syndrome; MDS) [74]. This evidence concerns the gene STAG2 and chronic myelogenous leukemia, BCR-ABL1 positive.