Figure 3A shows that the expression of TNFSF11 in the IL-1β group was higher than that in the control group, and the expression of TNFSF11 in the IL-1β + AT group was significantly lower than that in the IL-1β group, thereby indicating that TNFSF11 was upregulated in IL-1β-induced OA and downregulated after AT treatment. This evidence concerns the gene TNFSF11 and ataxia telangiectasia.