TP53 and neoplasm: Interestingly, our in silico analysis correlated with the qPCR validation of the chemokines and cytokines that were upregulated (Ccl2, Cxcl5, Ccl5, Cxcl16, Il6) and downregulated (Il17c, Il33, St2) in the p53-KD compared to control ROC1-tumor cells (Fig. 4e).