In addition, p53-KD in ROC1-tumor cells lead to high protein secretion levels of pro-MMP9, a metalloprotease that can digest extracellular matrix, and the chemokines IL10, CCL2, CCLl5, and CXCL16, which can attract CD8+ T and NK cells, suggesting a strong immune response toward the ROC1 p53-KD cells in the immunocompetent mouse model42–47. The gene discussed is MMP9; the disease is neoplasm.