Bioinformatic studies detected acquired mutations in p53, Fat1, Notch1, Csmd3, Kmt2d, Fat3, Fat4, Akap9, Med12l, and Myh6, in murine ROC cell lines (Fig. 1d), as reported previously in other murine oral cancer lines and human HNSCC28–33. This evidence concerns the gene KMT2D and lip and oral cavity carcinoma.