Bioinformatic studies detected acquired mutations in p53, Fat1, Notch1, Csmd3, Kmt2d, Fat3, Fat4, Akap9, Med12l, and Myh6, in murine ROC cell lines (Fig. 1d), as reported previously in other murine oral cancer lines and human HNSCC28–33. The gene discussed is AKAP9; the disease is lip and oral cavity carcinoma.