In agreement with our gene expression studies, p53-KD ROC1-tumor cells showed an upregulation and secretion of cytokines and chemokines, including IL-10, C-C motif chemokine ligand 2 (CCL2), CCL5, CCL20, C-X-C motif chemokine ligand 9 (CXCL9), CXCL12, CXCL16, and pro-matrix metallopeptidase 9 (MMP9) (Fig. 4f), soluble factors that promote the infiltration and activation of CD8+ T cells and natural killer (NK) cells in tumors42–47. The gene discussed is CXCL12; the disease is neoplasm.