Bioinformatic studies detected acquired mutations in p53, Fat1, Notch1, Csmd3, Kmt2d, Fat3, Fat4, Akap9, Med12l, and Myh6, in murine ROC cell lines (Fig. 1d), as reported previously in other murine oral cancer lines and human HNSCC28–33. Here, NOTCH1 is linked to lip and oral cavity carcinoma.