POLE and colorectal cancer: For example, DNA mismatch repair deficiency is represented by SBS6 and SBS15 (in colorectal and uterine cancers), POLE-deficiency-associated SBS10 (in colorectal cancers), ultraviolet (UV)-related SBS7 (in skin melanomas), tobacco-related SBS4 (in lung cancers), BRCA-deficient SBS3 (in breast and ovary cancers), SBS17 (in esophageal cancers), and SBS9 (in hematologic cancers).