Whilst the presence of multiple mutations per patient are commonly detected in blast crisis CML, acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) [29–31], 47/53 (89%) of all affected patients in this study showed only one mutation in addition to BCR::ABL1 at diagnosis indicating that the clonal architecture in CML might be less complex compared to other myeloid malignancies (Fig. 1). Here, ABL1 is linked to blast phase chronic myelogenous leukemia, BCR-ABL1 positive.