In addition, we determined that the CGI of AATK was methylated in 100% of seven pancreatic cancer cell lines (Hup-T3, Capan-1, PATU-S, Capan-2, PATU-T, PaCa2, PATU-02) and pharmacologically inhibiting DNMTs with 5-Aza-2′-deoxycytidine led to demethylation and re-expression of AATK (Fig. S3A–D). Here, AATK is linked to familial pancreatic carcinoma.