Additionally, KEGG analysis revealed higher significance among pathways involving cell cycle and SLE in 65-79*LE-stimulated cells, while the higher statistically significant KEGG pathways terms in 65-79*SE-stimulated cells included TNF signaling pathways and several TNF-dependent disease processes, including RA (Supplementary Fig. 3e), consistent with the established disease associations of the two respective coding DRB1 alleles. Here, TNF is linked to systemic lupus erythematosus.