STAT1 and systemic lupus erythematosus: The top predicted URs in 65-79*LE-activated transcriptome included several IFN-I regulators, such as interferon regulating factor 9 (IRF9), as well as two of its interacting proteins, signal transducer and activator of transcription (STAT) 2 and STAT1, previously implicated in SLE pathogenesis25–27.