As supplementary Fig. 8 demonstrates, in the presence of IFN-γ, BMDMs from LE-Tg mice, but not from control, SE-Tg mice, showed increased gene expression of several known SLE-associated IFN-I genes, such as Ifi44, Ifi44l, and Irf7, along with markedly curtailed expression of Dnase1l3, a gene known to protect against SLE in both humans and mice45–47. This evidence concerns the gene IFNG and systemic lupus erythematosus.