It is worth noting, however, that a recent association study of SLE using Immunochip genotyping data52 identified differential risk associations at a single amino acid residue level between the DRB1*15 allele, in which risk-associated residues were found primarily inside the peptide-binding pocket, and allele DRB1*03:01, in which risk-associated residues were found primarily at the region 70-77 of the DRβ chain, overlapping with the cusp region (amino acid residues 65-79). Here, HLA-DRB1 is linked to systemic lupus erythematosus.