IFNG and systemic lupus erythematosus: In this context, it is of interest that while both Model A (epitope + IFN-γ versus IFN-γ alone) and Model B (epitope + IFN-γ versus epitope alone) of RNA-seq data analysis uncovered bioinformatics evidence of a lupus signature transcriptome activation by the LE, Model B was found to be more robust in both mouse and human macrophages.