AR and neoplasm: Development of HGPIN and prostate adenocarcinomas in R26mTmG/hAR:Osr1Cre/+ mice but not in R26mTmG/+:PBCre/+ counterparts, aligning with the identification of hARtg+ atypical and tumor cells specifically within those HGPIN and prostate adenocarcinomas lesions, demonstrates the direct role of transgenic AR expression in inducing PIN and PCa development10.