Development of HGPIN and prostate adenocarcinomas in R26mTmG/hAR:Osr1Cre/+ mice but not in R26mTmG/+:PBCre/+ counterparts, aligning with the identification of hARtg+ atypical and tumor cells specifically within those HGPIN and prostate adenocarcinomas lesions, demonstrates the direct role of transgenic AR expression in inducing PIN and PCa development10. This evidence concerns the gene AR and prostate adenocarcinoma.