Additionally, development of both HGPIN and prostatic adenocarcinoma lesions in the AR transgenic mice regulated through Osr1-Cre but not PB-Cre implicates the critical cellular properties of prostatic Osr1-expressing cells and their derivatives, termed Osr1-lineage cells, in initiating oncogenesis and tumor development10. This evidence concerns the gene OSR1 and prostate adenocarcinoma.