However, activation of the “floxed” human AR transgene (hARtg) expression in a subpopulation of prostatic progenitors through the Osr1 (odd skipped related1) promoter-driven Cre recombinases developed high-grade prostatic intraepithelial neoplasia (HGPIN) and invasive prostatic adenocarcinoma (PCa) lesions in mice10. This evidence concerns the gene OSR1 and prostate intraepithelial neoplasia.