TGFB1 and non-small cell lung carcinoma: Consistent with our in vitro study, loss of RGS6 promoted TGF-β-induced NSCLC metastasis in vivo, indicated by significantly higher numbers of MOMNs in lung tissues from mice injected with RGS6-Cas9-1 or RGS6-Cas9-2 NSCLC cells (Supplementary Fig. 4B, C), as well as by significantly more micrometastases in lung (Supplementary Fig. 4D) and liver (Supplementary Fig. 4E) tissues from these mice.