RGS6 overexpression impaired TGF-β-induced upregulation of PAI-1 protein level in NSCLC cells with little effect on basal level of PAI-1 (Fig. 4C), suggesting that the effect of RGS6 on PAI-1 promoter activity is TGF-β-dependent. Here, SERPINE1 is linked to non-small cell lung carcinoma.