Consistent with the result of TCGA analysis (Fig. 1A), a pattern of downregulation of RGS6 expression was indicated by the lower overall mRNA levels of RGS6 in tumor tissues compared with noncancerous lung tissues (Fig. 1B), and by reduced T/N (Tumor/Normal, i.e RGS6 levels in tumor tissues/RGS6 levels in paired normal tissues) ratios of RGS6 levels found in 84.7% (78 out of 92) examined human lung cancer cases (Fig. 1C). Here, RGS6 is linked to lung cancer.