Consistently, we discovered that expression levels of PAI-1 and SNAI1 genes were inversely correlated with the levels of RGS6 in LUAD patients by analyzing TCGA dataset (Fig. 4G, H), suggesting that RGS6 suppresses TGF-β-induced activation of Snail and PAI-1 in both NSCLC cells and tissues. This evidence concerns the gene SERPINE1 and non-small cell lung carcinoma.