CDK5 and cancer: Cyclins and cyclin-dependent kinases (CDKs) are major effectors of the cell cycle with key role in cancer [35, 36] where our data shows downregulation of key cell-cycle proteins such as cyclin D1 and Geminin (Fig. 2E) and mRNA levels of CCNE1, CCNF, CDK1, CDK2 and CDK5 (Fig. 2G).