We also found that cholinesterase inhibitors and N-methyl-d-aspartate receptor antagonist were the two most widely used types of medication for dementia management [42, 43], as recommended by the current National Institute for Health and Care Excellence (NICE) guidance for people with Alzheimer’s disease (https://www.nice.org.uk/guidance/cg42). This evidence concerns the gene BCHE and early-onset autosomal dominant Alzheimer disease.