In keeping with results from lung adenocarcinoma (LUAD) and other solid tumors, we found implications for higher T cell infiltration in tumors with high CD73 expression levels on immune cells suggesting a rationale for the combination of therapeutic CD73 inhibition and ICI (Roh et al. 2020; Rocha et al. 2021; Reinhardt et al. 2017; Goswami et al. 2020). Here, NT5E is linked to lung adenocarcinoma.