Of note, dystrophin‐lacking skeletal muscles are characterised by significantly impaired Ca2+‐release from the sarcoplasmic reticulum in muscular dystrophy [43, 44, 45, 114] and the dystrophic phenotype of abnormal excitation–contraction coupling is exacerbated in dystrophin/utrophin double‐KO fibres [115]. The gene discussed is DMD; the disease is muscular dystrophy.