TP53 and nonpapillary renal cell carcinoma: Additionally, transcription of the DREAM target genes CDK1, cyclin B1, cyclin B2, and PLK1 is less efficiently repressed when PBRM1 is depleted (Fig. 4G), suggesting that the p53-dependent DREAM pathway is also dependent on PBRM1 in the Caki-1 ccRCC cell line.