VEGFA and neoplasm: Additionally, because there was an endoscopically-visible reduction in tumor size between each therapy cycle in the MTD group (Figure 1C), the reduction in Vegf expression, and similar trends in the increase of StO2 and HbO2 would indicate a reduction in oxygen demand in surrounding tissue due to the number of tumor cells killed after each round of therapy driven by an anti-angiogenic effect in MTD NAC, consistent with results we have previously reported [27].