HIF1A and neoplasm: In this case, at the very least, the similar levels of expression, longitudinal trends obtained for both genes, and the visually observable reduction in tumor size that MTD NAC causes suggest that in primary colorectal malignancies MTD NAC is able to effectively disrupt the VEGF-HIF-1a axis, thereby leading to a lasting anti-angiogenic effect that is not observable in MET NAC.