Increased levels of MMP2 proteins degrade the matrix and collagen tissues in the intercellular stroma; this opens up a channel for the infiltration and migration of tumor cells, which invade the basement membrane and enter the circulatory system.[34] Our bioinformatics analysis showed a positive correlation between MMP2 expression and FBN1, which was verified using BLI experiments; these results demonstrated that FBN1 interacts with MMP2. The gene discussed is FBN1; the disease is neoplasm.