Upregulationof ACE2 in the diseased brain has been observed as a result of otherconditions, for example, Alzheimer’s disease35 and hypertension,36 and in thepresent investigation, endothelial cells were distinctly stained withinbrain tumor cell compartments of a COVID-19 patient operated for braintumor. This evidence concerns the gene ACE2 and brain neoplasm.