ERN1 and periodontitis: It was found that overlapping targets of ferroptosis-related genes in periodontitis were involved in 34 pathways by using ClueGO analysis, including regulation of glutathione biosynthetic, glutamate homeostasis, ER-nucleus signaling pathway, response to gamma radiation, protein folding chaperone, positive regulation of B cell proliferation, protein serine/threonine kinase inhibitor activity, and so on (Fig 6).