The proportion of uncorrected CHD cohort with coagulation abnormalities, defined as thrombocytopaenia, prolonged prothrombin time and/or activated partial thromboplastin time and elevated D-dimer assay was 26 (37.1%), which was much higher than 5 (7.1%) in apparently healthy controls as shown in Fig 1. The gene discussed is F2; the disease is Abnormality of coagulation.