To verify that these TFs indeed contribute to the regulation of Na/K-ATPase gene and other genes in this gene module, we compared the expression level of the three TFs in the heart-transplant DCM patients and their donors from the RNA-sequencing data and found that EOMES level was significantly increased to more than two-fold in DCM patients compared to that in non-heart failure donors, but BHLHE-40 and RFX1 were not significantly changed. Here, RFX1 is linked to familial dilated cardiomyopathy.