Finally, to determine how the inflammatory milieu in psoriasis might contribute to the observed changes in epidermal lipid expression, we cultured 50 primary keratinocyte cell lines in parallel with the psoriasis-associated cytokines IFN-γ, IL-17A, and TNF and then characterized the expression of their lipid-associated metabolic genes by RNA-Seq. This evidence concerns the gene TNF and psoriasis.