For example, in a Men1 knockout mouse model, loss of cell-cycle control and pituitary tumourigenesis were associated with miR-15a, miR-16-1 and let-7a downregulation and cyclin D1 upregulation in pituitary adenomas compared to normal WT pituitaries (Lines et al. 2018). Here, MEN1 is linked to pituitary gland adenoma.