INS and diabetes mellitus: In a subgroup analysis, a decrease in HbA1c levels among the 3 groups showed a significant difference only at 12 weeks, especially in the patients aged <65 years (P=.02), patients with a diabetes duration of ≥10 years (P=.02), patients with a BMI of ≥25.0 kg/m2 (P=.004), patients with a C-peptide level of ≥0.6 ng/mL (P=.008), and patients who did not undergo treatment with insulin (P=.004; Table S2 in Multimedia Appendix 2).