The above results confirmed that the clone formation, invasion, and migration abilities of both CRC cells decreased significantly after the knockdown of NOTCH3 or SMARCA4, and the difference was statistically significant (Fig. 4C–N), which revealed that both NOTCH3 and SMARCA4 are involved in the regulation of growth, invasion, and migration of CRC cells. The gene discussed is SMARCA4; the disease is colorectal carcinoma.