NOTCH3 may target MUC5AC and MUC2 by recruiting transcription activator BRG1 (SMARCA4) to regulate the growth, invasion, and migration of CRC cells, which involving in the differentiation and development of mucinous colorectal adenocarcinoma (MCA), indicating a novel molecular mechanism of occurrence of MCA mediating by NOTCH3. Here, NOTCH3 is linked to colorectal mucinous adenocarcinoma.