In addition, GSEA analysis was also performed using the TCGA dataset, and, on calculating the pathway Enrichment Score (ES), it was found that the gene sets of LIU_SMARCA4_TARGETS, HENDRICKS_SMARCA4_TARGETS_UP, and MEDINA_SMARCA4_TARGETS were enriched by the higher expression of NOTCH3 (Fig. 1D) in CRC, which suggested that the high expression of NOTCH3 in CRC could activate the downstream signaling pathway of SMARCA4. Here, NOTCH3 is linked to colorectal carcinoma.