In addition, the possible targeting factors of NOTCH3 and SMARCA4 in colon cancer cells were screened through RNA‐seq, and, for the first time, we identified that MUC5AC and MUC2 may be the targeted factors for the co‐regulation of NOTCH3 and SMARCA4 interaction (Fig. 6A,B). Here, NOTCH3 is linked to malignant colon neoplasm.