Like overexpression of the other pro-survival proteins BCL-2, MCL-1, BCL-XL and BCL-W, overexpression of BFL-1 has been shown to accelerate MYC-driven myeloid leukemogenesis [7], as well as MYC-driven lymphomagenesis in the Eμ-Myc mouse model of B cell lymphoma [8]. This evidence concerns the gene BCL2A1 and B-cell non-Hodgkin lymphoma.