FCGR3A and cancer: Despite all of the variants except AvFcΔlec recognizing the cancer cell surface to similar degrees, kinetic analysis of binding to FcγRs by surface plasmon resonance (SPR) showed that the AvFcΔXF variant had ≈2‐fold increased affinity to human FcγRI (hFcγRI), ≈4‐fold increased affinity to human FcγRIIIa (hFcγRIIIa) and ≈5.5‐fold increased affinity to mouse FcγRIV (mFcγRIV) compared with AvFcWT (Figure 2).