We have previously reported that AvFc recognizes a large number of cancer cell lines through this mechanism and that by binding to mannosylated forms of EGFR and IGF1R derived from lung cancer cell lines and tissues in addition to inducing ADCC, AvFc displays potent activity against A549 and H460 lung cancer both in vitro and in vivo (Oh et al., 2022). Here, IGF1R is linked to lung cancer.