The expression of Enpp1, Slc20a2, Ank, Bglap, Pdpn, Runx2, Bmp2, Npnt, and Tnfrsf11b was decreased, whereas femoral expression of Fgf23, and Adipoq, was increased in CKD mice when compared to control mice (Fig. 1A). Here, NPNT is linked to chronic kidney disease.