The expression of Enpp1, Slc20a2, Ank, Bglap, Pdpn, Runx2, Bmp2, Npnt, and Tnfrsf11b was decreased, whereas femoral expression of Fgf23, and Adipoq, was increased in CKD mice when compared to control mice (Fig. 1A). The gene discussed is SLC20A2; the disease is chronic kidney disease.