To compare the global difference of paired BCR repertoire between SARS-CoV-2 infection and vaccination, we collected PBMCs from six healthy recipients with three shots of BBIBP-CorV (the Vaccinated Healthy group), and those people in 0 d before vaccination (the Healthy group) were considered as the baseline, five people who had recovered from COVID-19 and had received a single dose of SARS-CoV-2 inactivated virus vaccine (the Vaccinated Recovered group), and five COVID-19 recovered people (the Unvaccinated Recovered group), respectively. The gene discussed is BCR; the disease is COVID-19.