TRIM8 and toxic encephalopathy: The third module included 3 genes in Neurotoxicity (Itpr1, Trim8, Lrp1), 4 in Blood–brain barrier (Ptpn23, Claudin5, Plectin, Mmp2) and 4 in Cognitive function (Slc8a3, Srf, Nf1, Ncam1; Figures 11 and 12).