The main molecular mechanisms of JWHLGJD for CRA consisted of 30 signaling pathways, and the key pathways that were closely related to CRA were found to be related to cell proliferation, apoptosis, and metabolic dysregulation through the pathways in cancer, lipid and atherosclerosis, PI3K-Akt signaling pathway, and MAPK signaling pathway. This evidence concerns the gene AKT1 and atherosclerosis.