Urine (TIMP-2) × (IGFBP7) > 0.3 was used to define patients at high risk of post-operative AKI and to guide intensive care in KDIGO guidelines, including volume optimization, hemodynamic stability, avoidance of nephrotoxic drugs, prevention of hyperglycemia, etc. It reduced the incidence and severity of post-operative AKI compared to standard care (44). The gene discussed is TIMP2; the disease is acute kidney injury.