Upregulation of ALG3 promoted the progression of cervical cancer (Choi et al., 2007) and non–small-cell lung cancer (Ke et al., 2020) and was proven to be associated with lymph node metastasis in esophageal squamous cell carcinoma (Shi et al., 2014). Here, ALG3 is linked to esophageal squamous cell carcinoma.