Mechanistically, It has been confirmed that miR-15a-5p exerts its anti-pancreatic cancer activity by directly targeting FGFR1, which is highly expressed and executes cancer-promoting actions in PAAD (Turner et al., 2008; Lehnen et al., 2013; Coleman et al., 2014). This evidence concerns the gene FGFR1 and familial pancreatic carcinoma.