In summary, through the integration of several bioinformatics analyses, we constructed a reverse mRNA model based on the LINC00511, LINC01578, PVT1, TNFRSF14-AS/hsa-miR-15a-5p/COL1A2, ITGA2, ITGB6, LAMA3, LAMB3, and LAMC2 ceRNA network, which can enhance our understanding of the development of PAAD. This evidence concerns the gene LAMB3 and pancreatic adenocarcinoma.