Our investigation of EP3 protein expression on the human ocular surface showed that the EP3 protein level was much lower in the conjunctival epithelium of patients with SJS/TEN with SOC than in the controls, that is, patients with conjunctival chalasis or chemical burns (Ueta et al., 2010a; Ueta et al., 2011a). Here, PTGER3 is linked to toxic epidermal necrolysis.