In patients with SJS/TEN with SOC, the plasma level of miR-628-3p miRNA was significantly elevated and this miRNA could silence the mRNA expressions of pathogen-associated molecular patterns (PAMPs) of TLR3, RIG-I, MDA5, and other innate immune-related molecules, such as IFI44L, CXCL11, TNFSF10, RSAD2, CXCL10, and CCL8 (Ueta et al., 2021). Here, TLR3 is linked to toxic epidermal necrolysis.