Although there are some reports on oligoclonal T cell populations showing HLA restriction and drug reactivity for HLA-B*58:01 restricted allopurinol-SJS/TEN (Lin et al., 2015) and HLA-B*15:02 restricted carbamazepine-SJS/TEN (Wei et al., 2012), there are few reports on T cell-mediated mechanisms in CM-related SJS/TEN with SOC, suggesting that more investigations are required to elucidate the pathogenic mechanisms of CM-related SJS/TEN with SOC. The gene discussed is HLA-B; the disease is cutaneous mastocytosis.