This suggests that EP3 expression might be strongly downregulated on the ocular surface of patients with SJS/TEN with SOC and that the downregulation of EP3 protein expression might contribute to ocular surface inflammation in these patients (Ueta et al., 2010a; Ueta et al., 2011a; Ueta and Kinoshita, 2012; Ueta, 2021a). This evidence concerns the gene PTGER3 and toxic epidermal necrolysis.