Since CM-related SJS/TEN with SOC developed in patients after taking CMs for the common cold due to some viral or mycoplasma infection, we suspected that not only CMs, miRNAs such as hsa-miR-628-3p, and the interaction of susceptibility genes such as TLR3, PTGER3 (which ligand, PGE2 is downregulated by cold medicines such as NSAIDs, acetaminophen, and dipyrone), and IKZF1 but also some microbial infections are important and necessary for triggering the onset of SJS/TEN with SOC (Ueta and Kinoshita, 2012; Ueta, 2016; Ueta, 2018; Ueta, 2020; Ueta, 2021a) (Figure 2). This evidence concerns the gene PTGER3 and toxic epidermal necrolysis.