We also found that PTGER3 is a susceptibility gene for CM-related SJS/TEN with SOC (Ueta et al., 2010a) and that HLA-A*02:06 and PTGER3 polymorphisms exerted additive effects in Japanese and Korean patients with CM-related SJS/TEN with SOC (OR = 10.8 and 14.2, respectively) (Ueta et al., 2015b). This evidence concerns the gene PTGER3 and toxic epidermal necrolysis.