As CXCL10 is highly induced by the TLR3 ligand poly(I:C) in human corneal and conjunctival epithelial cells (Ueta et al., 2010b), it is possible that abnormal innate immunity is involved in the presence of TLR3 on the ocular surface of SJS/TEN with SOC (Ueta and Kinoshita, 2012; Ueta, 2016; Ueta, 2018; Ueta, 2021a). The gene discussed is TLR3; the disease is toxic epidermal necrolysis.