We have analyzed the association between CM-related SJS/TEN with SOC and HLA genotypes, and found that CM-related SJS/TEN with SOC was significantly associated with HLA-A*02:06 [151 patients, 639 normal controls; odds ratio (OR) = 5.6, p = 2.7 × 10–20] and with HLA-B*44:03 in the Japanese (151 patients, 639 normal controls; OR = 2.0, p = 1.3 × 10–3) (Ueta et al., 2014a). This evidence concerns the gene HLA-B and toxic epidermal necrolysis.