Moreover, the associated HLA types vary among different causative drugs; for example, HLA-B* 58:01 for allopurinol (Hung et al., 2005; Tohkin et al., 2013), HLA-B*15:02 (Chung et al., 2004; Kaniwa et al., 2008; Kaniwa et al., 2013), HLA-A*31:01 (McCormack et al., 2011; Mockenhaupt et al., 2019), HLA-B*57:01 (Mockenhaupt et al., 2019) for carbamazepine, and HLA-A*02:06 and HLA-B*44:03 for CM-related SJS/TEN with SOC (Ueta et al., 2014a; Ueta et al., 2014b). This evidence concerns the gene HLA-A and toxic epidermal necrolysis.