INS and Insulin resistance: In fact, it has been demonstrated that it is a key regulator of insulin sensitivity since mice with Ptp1b gene deletion present a reduction of insulin resistance, turning it into a promising target not only for the design of anti-diabetic drugs (Elchebly et al., 1999; Zhang and Lee, 2003) but also to elude synaptic alteration and cognitive loss (Fuentes et al., 2012; Ricke et al., 2020), since PTP1B activity in the hippocampus has been correlated with impaired neuronal insulin signaling (Wang et al., 2017).