Regarding synaptophysin, the reduction of this glycoprotein, which predominates in the synaptic vesicles, has been related to memory impairment (Zhang et al., 2019; Du et al., 2020) In this context, as it has been previously commented, obesity also plays a key role in the correct function of memory interconnecting these three concepts (Daniels et al., 2005; Kalarchian and Marcus, 2012). Here, SYP is linked to obesity due to melanocortin 4 receptor deficiency.