Therefore, the aim of the study is to determine the role of PPARβ/δ in the neuropathological pathways involved in the development of memory impairment and as to whether a risk factor involved in cognitive loss and in the development of T2DM such as obesity (high-fat diet, HFD) consumption) modulates hippocampal neuropathological markers in mice lacking this nuclear receptor. This evidence concerns the gene PPARD and obesity disorder.