The expressions of NRF2, HO-1, and GPX4 were significantly lower in the caryophyllene oxide group (50 mg/kg, 100 mg/kg, and 200 mg/kg) than those in the control group (Figures 8C,D; p < 0.05 or p < 0.01), indicating that caryophyllene oxide suppresses the expression of antioxidant proteins in tumor tissue and reduces the degree of anti-oxidation. The gene discussed is GPX4; the disease is neoplasm.