In this experiment, caryophyllene oxide could decrease the expression of NRF2 protein in vivo and in vitro, thus inhibiting the expression of HO-1, GPX4, and NQO1; intracellular antioxidant levels; and the expression of GSH in serum and scavenge hydroxyl radicals, which influence the oxidation level in tumor tissues. Here, HMOX1 is linked to neoplasm.