NOS2 and Hyperglycemia: Consistent with attenuating the destructive effects of oxidative stress, presented evidence showed that Moringa oleifera extracts could effectively reduce the elevated levels of pro-inflammatory mediators such as tumor necrosis factor alpha (TNF-α), IL-1β, IL-6, cyclooxygenase-2 (COX-2), nitric oxide synthase (iNOS), and chemokine (MCP-1) to protect against exacerbated inflammation, under sustained conditions of hyperglycemia (Muhammad et al., 2016; Omodanisi et al., 2017a; Azevedo et al., 2018).