Also, individuals with T2D display classic signatures of oxidative stress by presenting significantly decreased levels of antioxidant mechanisms such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), and heme oxygenawe-1 (HO-1) (Matough et al., 2012; Sharma et al., 2012; Dumanović et al., 2021). The gene discussed is CAT; the disease is type 2 diabetes mellitus.