NOS2 and Hyperglycemia: This is an essential result since tenacious hyperglycemia, seen in T1D, is already known to mediate iNOS induction, leading to the activation of protein kinase enzymes such as PKC/c-Jun N-terminal kinases (JNKs)/mitogen-activated protein kinase (MAPK) to propagate the detrimental effects of inflammation (Giacco and Brownlee, 2010).