Significantly, such positive effects were associated with reduced nephrotoxic and hepatotoxic damage (Oguntibeju, 2019), including upregulation of an angiogenic marker vascular endothelial growth factor (VEGF) to protect against hyperglycemia-induced wound injury in a preclinical model of T1D (Muhammad et al., 2016). Here, VEGFA is linked to Hyperglycemia.