Multivariate Cox regression adjusted for age, gender, histology type, smoking status, stage, and metastasis showed that the MAD2L2 rs746218 polymorphism was significantly related to PFS in patients with lung cancer in the recessive model (p = 0.039, OR = 5.31, and 95% CI = 1.09–25.93) (Table 3). The gene discussed is MAD2L2; the disease is lung cancer.