GPBAR1 and autoimmune hepatitis: The decreased abundance of Clostridium in AIH brings about the decrease of secondary bile acid (Kayama et al., 2020), which inhibits the polarization of NKT 10 cells from NKT cells and the secretion of anti-inflammatory cytokines IL-10 via the inactivation of GPBAR1, thereby alleviating liver injury in Con A-induced hepatitis (Biagioli et al., 2019).