The activated AhR-CYP1A1 pathway induces the production of TFH cells and Th17 cells (Veldhoen et al., 2008; Moura-Alves et al., 2014; Schiering et al., 2017), which is conducive to the secretion of systematic autoantibodies, thus putatively participating in the initiation of AIH (Manfredo Vieira et al., 2018). This evidence concerns the gene CYP1A1 and autoimmune hepatitis.