BRAF and colorectal carcinoma: Activating V600 mutations in theBRAF gene are considered mutually exclusive withRAS mutations and occur in approximately 10% of mCRC cases.BRAF V600E mutations tend to be enriched in right-sidedtumors and tumors with high microsatellite instability (MSI-H).53, –55 Compared withBRAF wild-type CRC, tumors harboring BRAFV600E mutations have been independently correlated with worse survival and rapiddisease progression following first-line chemotherapy.54, –56