Wang et al. (2019) found that exosomes secreted by AML cells can enhance glycolysis-mediated vascular remodeling and chemoresistance. According to previous reports, wogonoside inhibits angiogenesis in solid tumors by blocking the JAK2-STAT3 pathway and inhibiting the development of hematologic malignancies in AML (Lin et al., 2019). This evidence concerns the gene STAT3 and acute myeloid leukemia.