In summary, this study shows that GPX2, a key oncogene, plays an important role in cell proliferation, migration, invasion, and apoptosis, providing a potential target for new therapeutic strategies to prevent and control the development of lung adenocarcinoma, and the molecular mechanism of GPX2 in the occurrence and progression of lung adenocarcinoma still needs to be further explored. The gene discussed is GPX2; the disease is lung adenocarcinoma.