In this study, we analyzed the expression and prognosis of GPX2 in lung adenocarcinoma based on bioinformatics and found that the expression level of GPX2 was significantly higher in lung adenocarcinoma tissues compared with normal lung tissues, which initially confirmed that reduced GPX2 expression was associated with the prognosis of lung adenocarcinoma. Here, GPX2 is linked to lung adenocarcinoma.