When PD-1 or PD-L1 was given with CTLA-4 (Group L), the risk of developing rash was higher than that of CTLA-4 subgroup (OR = 1.43, 95% CI: [1.06, 1.93]; I2 = 0%, Z = 2.32, p=0.02; Figure 5(i)). This evidence concerns the gene CTLA4 and Skin rash.