For PD-1/PD-L1 alone, the risk of rash was significantly increased when they were given with chemotherapy (OR = 2.33, 95% CI: [1.15, 4.75]; I2 = 81%, Z = 2.34, p=0.02; Figures 4(e) and 4(f)). This evidence concerns the gene CD274 and exanthem.